Diagnostic Pathology: Placenta

Diagnostic Pathology: Placenta is designed not only for practicing pathologists and pathologists-in-training, but for anyone interested in fields related to placental pathology. Comprehensive yet easily accessible, this medical reference book provides clear and concise information on topics including gross and microscopic changes of the placenta, common diagnoses, and placental evaluation in special circumstances. .

Table of Contents:

PART 1: OVERVIEW GROSS AND MICROSCOPIC CHANGES

SECTION I: UMBILICAL CORD

Gross Evaluation and Normal Histology of Umbilical Cord

Knots

Umbilical Cord Edema and Thinning

Histopathologic Changes of Umbilical Cord

SECTION II: EXTRAPLACENTAL MEMBRANES

Gross Evaluation and Normal Histology of Membranes

Histopathologic Changes of Membranes

SECTION III: CHORIONIC PLATE

Gross Appearance and Normal Histology of Chorionic Plate

Histopathologic Changes of Chorionic Plate

SECTION IV: STEM VILLI

Gross Appearance and Normal Histology of Stem Villi

Histopathologic Changes of Stem Villi

SECTION V: CHORIONIC VILLI

Gross Appearance and Normal Histology of Chorionic Villi

Histopathologic Changes of Chorionic Villi

SECTION VI: DECIDUA

Gross Appearance and Normal Histology of Decidua

Histopathologic Changes of Decidua

PART 2: DIAGNOSES

Hydropic Degeneration and Hydatidiform Mole

Choriocarcinoma Placental Site Nodule and Exaggerated Placental Site

Placental Site Trophoblastic Tumor and Epithelioid Trophoblastic Tumor

SECTION I: MECONIUM

Meconium-Stained Placenta

SECTION II: AMNIOTIC FLUID INFECTION SEQUENCE

Amniotic Fluid Infection Sequence (Maternal and Fetal Inflammatory Response)

Group B Streptococcus

Other Bacterial and Mycobacterial Species

Candida Infection

SECTION III: VILLITIS ASSOCIATED WITH SPECIFIC INFECTIONS

Cytomegalovirus

Parvovirus B19

Herpes Simplex Virus

Other Viruses

Syphilis

Coccidioidomycosis

Parasitic Infections

SECTION IV: CHRONIC VILLITIS OF UNKNOWN ETIOLOGY

Cellular Composition of Chronic Inflammatory Lesions

Chronic Villitis and Intervillositis

Basal Chronic Villitis and Chronic Deciduitis

Chronic Chorioamnionitis

Eosinophilic/T-Cell Chorionic Vasculitis

SECTION V: MASSIVE PERIVILLOUS FIBRIN DEPOSITION AND MATERNAL FLOOR INFARCTION

Massive Perivillous Fibrin Deposition and Maternal Floor Infarction

SECTION VI: FETAL VASCULOPATHY

Large Vessel Fetal Vascular Occlusion

Distal Villous Lesions of Fetal Vascular Occlusion

SECTION VII: PLACENTAL ABRUPTION

Acute Abruption and Retroplacental Hematoma

Chronic Abruption

SECTION VIII: VILLOUS HYPERVASCULAR LESIONS

Chorangiosis

Chorangiomatosis

Chorangioma

SECTION IX: METASTES TO THE PLACENTA

Metastatic Tumors

SECTION X: PLACENTAL MESENCHYMAL DYSPLASIA

Placental Mesenchymal Dysplasia

PART 3: PLACENTAL EVALUATION IN SPECIAL CIRCUMSTANCES

SECTION I: CHANGES CONSISTENT WITH GESTATIONAL DIABETES

Gestational Diabetes

Placentomegaly

Distal Villous Immaturity

SECTION II: PREECLAMPSIA AND OTHER DISORDERS

Preeclampsia and Related Hypertensive Disorders

Small for Gestational Age Placenta

Distal Villous Hypoplasia

Maternal Decidual Vasculopathy

Infarcts

Extravillous Cytotrophoblast Cysts

Laminar Necrosis of Decidua

SECTION III: FETAL-MATERNAL HEMORRHAGE

Fetal-Maternal Hemorrhage

SECTION IV: PLACENTAL EVALUATION FOR SMALL FOR GESTATIONAL AGE INFANT

Placental Causes of Poor Fetal Growth

SECTION V: PLACENTAL EVALUATION IN PREMATURITY

Premature Birth

SECTION VI: PLACENTAL EVALUATION IN ABNORMAL PLACENTAL IMPLANTATION

Placenta Accreta

SECTION VII: PLACENTAL EVALUATION IN INTRAUTERINE FETAL DEMISE

1st Trimester

2nd Trimester

3rd Trimester

Recurrent Pregnancy Loss

In Utero Demise to Delivery Interval Changes

SECTION VIII: PLACENTAL EVALUATION IN MULTIPLE GESTATIONS

Complications of Monochorionic Monoamnionic Gestations

Twin Growth Discrepancy

Twin-Twin Transfusion Syndrome

After In Utero Intervention for Twin-Twin Transfusion Syndrome

Triplet and Higher Order Placenta

SECTION IX: THE POSTPARTUM HYSTERECTOMY

Evaluation of Postpartum Hysterectomy

Postpartum Hemorrhage

PART 4: APPENDIX

SECTION I: REFERENCE CHARTS FOR PLACENTAL EVALUATION

Reference Value Weights for Singleton Placentas

Reference Value Weights for Twin Placentas

Reference Value Weights for Triplet Placentas

Reference Values for Fetal and Placental Growth in Early Pregnancy

SECTION II: SAMPLE TEMPLATES FOR PLACENTAL EVALUATION

Singleton Placenta Gross Evaluation Template

Twin Placenta Gross Evaluation Template

Placenta Microscopic Evaluation Template

Placenta Triage Template

Amy Heerema-McKenney, MD, Staff Pathologist, Cleveland Clinic Institute of Pathology and Laboratory Medicine, Cleveland, Ohio; Monique E De Paepe, MD, MSc, Professor of Pathology and Laboratory Medicine, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island and Edwina J Popek, DO, Professor of Pathology and Pediatrics, Baylor College of Medicine, Texas Children’s Hospital Pavilion for Women, Houston, Texas