The Obstetric Hematology Manual

Understand the rapidly growing complexities of Obstetric Hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.

    Fully updated to reflect the latest guidelines for examination and management of the conditions discussed
    Practical case scenarios at the end of chapters help readers to clearly see how the information applies to clinical practice; assisting personal patient interactions
    New edition features many more illustrations, including color reproductions of blood-films

Table of Contents

Part I. Physiological Changes in Pregnancy:
1. Normal cellular changes during pregnancy and the puerperium Margaret Ramsay
2. Normal coagulation changes during pregnancy Rachel Rayment
Part II. Cytopenia:
3. Iron deficiency in pregnancy Xiao Yin Zhang and Sue Pavord
4. Vitamin B12 and folate deficiencies in pregnancy Alesia Khan and Susan Robinson
5. Autoimmune cytopenias in pregnancy Hamish Lyall and Bethan Myers
Part III. Inherited Red Cell Disorders:
6. Management of sickle cell disease in pregnancy Karyn Longmuir and Jo Howard
7. Management of thalassemias in pregnancy Farrukh Shah
8. Screening for hemoglobinopathies Shirley Henderson and Josh Wright
9. Management of other inherited red cell disorders in pregnancy Noemi Roy and Sue Pavord
Part IV. Fetal Maternal Alloimmune Syndromes:
10. Fetal/neonatal alloimmune thrombocytopenia Mike Murphy
11. Red cell alloimmunization Alec McEwan
Part V. Thromboembolism and Anticoagulation:
12. Acute management of suspected thromboembolic disease in pregnancy Andrew Thompson, Beverley Hunt and Ian Greer
13. Thromboprophylaxis in pregnancy Anna Lawen-O'Brien and Catherine Nelson-Piercy
14. Management of prosthetic heart valves in pregnancy Claire McLintock
15. Management of anticoagulants at delivery Christina Oppenheimer, Paul Sharpe and Andrew Ling
Part VI. Thrombophilia and fetal loss:
16. Antiphospholipid syndrome Sue Pavord, Bethan Myers, Savino Sciascia and Beverley Hunt
17. Inherited thrombophilia and pregnancy loss Luuk Scheres, Isobel Walker and Saskia Middeldorp
Part VII. Hemorrhagic Disorders:
18A Management of obstetric hemorrhage: obstetric management Annette Briley and Susan Bewley
18B. Management of obstetric hemorrhage: anesthetic management Catherine Collinson and Arlene Wise
18C. Management of obstetric hemorrhage: hemostatic management Peter Collins and Rachel Collis
18D. Management of obstetric hemorrhage: radiological management Narayan Karunanithy
19. Management of inherited disorders of primary hemostasis in pregnancy Carolyn Millar and Sue Pavord
20. Management of inherited coagulopathies in pregnancy Sue Pavord
21. Genetic counseling and prenatal diagnosis of congenital bleeding disorders Nikki Curry and Andrew Mumford
Part VIII. Micrangiopathies:
22. Preeclampsia Eleftheria Lefkou and Beverley Hunt
23. Thrombotic thrombocytopenic purpura and other microangiopathies in pregnancy Pat O'Brien and Marie Scully
Part IX. Malignant conditions:
24. Myelproliferative neoplasms and pregnancy Susan Robinson and Claire Harrison
25. Management of acute haematological malignancy in pregnancy Sahra Ali and Gill Swallow
26. Late effects of chemo-radiotherapy on fertility and pregnancy Seonaid Pye and Nina Salooja.

Sue Pavord, FRCP, FRCPath, is a consultant hematologist at Oxford University Hospitals NHS Foundation Trust and Associate Senior Lecturer in Medicine at the University of Oxford.

Beverley Hunt, FRCP, FRCPath, MD, is Professor of Thrombosis and Haemostasis at King's College London, and is a consultant in the Departments of Pathology and Haematology at Guy's and St Thomas NHS Foundation Trust.

Contributors: Margaret Ramsay, Rachel Rayment, Xiao Yin Zhang, Sue Pavord, Alesia Khan, Susan Robinson, Hamish Lyall, Bethan Myers, Karyn Longmuir, Jo Howard, Farrukh Shah, Shirley Henderson, Josh Wright, Noemi Roy, Mike Murphy, Alec McEwan, Andrew Thompson, Beverley Hunt, Ian Greer, Anna Lawen-O'Brien, Catherine Nelson-Piercy, Claire McLintock, Christina Oppenheimer, Paul Sharpe, Andrew Ling, Savino Sciascia, Luuk Scheres, Isobel Walker, Saskia Middeldorp, Annette Briley, Susan Bewley, Catherine Collinson, Arlene Wise, Peter Collins, Rachel Collis, Narayan Karunanithy, Carolyn Millar, Nikki Curry, Andrew Mumford, Eleftheria Lefkou, Pat O'Brien, Marie Scully, Susan Robinson, Claire Harrison, Sahra Ali, Gill Swallow, Seonaid Pye, Nina Salooja