Multiple Sclerosis

Designed for both neurologists and non–neurologists, Multiple Sclerosis: Diagnosis and Therapy takes a practical approach to the most current principles of diagnosis and management of this complex disease. Editors and authors from Harvard Medical School have contributed up–to–date therapeutic information for the various stages and types of MS and also provide the necessary background regarding the pathogenesis of the disease. Multiple Sclerosis: a complex disease requiring sophisticated management Multiple Sclerosis poses labyrinthine challenges. There is no blood test to rely on for diagnosis; clinical acumen is essential. Yet an effective diagnosis only takes you part of the way: treatment offers further enigmas. The MS treatment landscape is complicated, and will become even more so with time. Multiple Sclerosis: Diagnosis and Therapy is the map you need to navigate this maze. Written and edited by leaders in the field, it guides you towards effective and positive choices for your patients. The diagnosis section provides state–of–the–art thinking about pathogenesis. With clear coverage of biomarkers, genetics, and imaging, it presents a coherent framework for making the correct diagnosis. The management section comprehensively covers current and future treatments to steer you through the many options for • Symptom management • Cognitive dysfunction • Depression and other mental health issues ‘Top Tips’ throughout provide the practical guidance you need for the best management of your patients. Multiple Sclerosis: Diagnosis and Therapy should be on the bookshelf of anyone who treats patients with multiple sclerosis. Howard L. Weiner, MD, Harvard Medical School, Brigham and Women′s Hospital & Partners MS Center, Boston, MA, USA James M. Stankiewicz, MD, Harvard Medical School, Brigham and Women’s Hospital & Partners MS Center, Boston, MA, USA Contents List of Contributors, vii Preface, ix Part I Pathology and Diagnosis, 1 1 Disease Pathogenesis, 3 Roopali Gandhi and Howard L. Weiner 2 Biomarkers, 26 Manuel Comabella and Samia J. Khoury 3 Epidemiology and Genetics, 56 Philip L. De Jager 4 Diagnosis, 77 James M. Stankiewicz, Varun Chaubal, and Guy J. Buckle 5 Pediatric Multiple Sclerosis and Acute Disseminated Encephalomyelitis, 101 Tanuja Chitnis 6 Magnetic Resonance Imaging in Multiple Sclerosis, 136 Mohit Neema, Antonia Ceccarelli, Jonathan S. Jackson, and Rohit Bakshi 7 Predicting Clinical Course, 163 Brian Healy and Maria Liguori Part II Management, 181 8 Medication Treatment in Multiple Sclerosis, 183 James M. Stankiewicz and Samia J. Khoury 9 Symptom Management, 213 Lynn Stazzone and Brandon Brown 10 Cognitive Dysfunction in Multiple Sclerosis, 239 Bonnie I. Glanz and Maria K. Houtchens 11 Depression and Other Psychosocial Issues in Multiple Sclerosis, 263 David J. Rintell 12 Future Therapeutic Approaches, 283 Howard L. Weiner and Laura Edwards Index, 301