Pediatric Liver Transplantation

Written and edited by global leaders in the field, Pediatric Liver Transplantation: A Clinical Guide covers all aspects of treatment and management regarding this multifaceted procedure and unique patient population. This practical reference offers detailed, focused guidance in a highly templated, easy-to-consult format, covering everything from pre-transplantation preparation to surgical techniques to post-operative complications.

Table of Contents:

    Evolution of transplantation medicine

    BRIEF HISTORY OF PLT

    HEALTH SYSTEM BACKGROUND REQUIREMENTS FOR PLT

    Before transplantation

    Brain death criteria

    Non-heart beating donors

    Donor procurement

    Managing a scarce resource: Differences in donor allocation across the world

    INDICATIONS AND CONTRAINDICATIONS (and their evolution) - General aspects

    (List of diagnoses)

    PREPARATION FOR PLT

    Medical (immunisations/cardiac/renal/neurological aspects)

    Surgical and Radiological aspects

    Psychological/Social aspects

    Paediatric liver transplantation

    ANAESTHETIC ASPECTS (Risk assessment)

    SURGICAL ASPECTS (Choice of donor for PLT, Prevention of thrombosis/anticoagulation)

    SURGICAL TECHNIQUES

    Split graft

    Living-related

    Auxiliary

    Domino

    Techniques and present role of hepatocyte transplantation

    STRATEGIES IN IMMUNE SUPPRESSION (Immune ablation, renal-sparing, steroid-sparing)

    Management after Transplantation

INTENSIVE CARE ASPECTS

ANTI-INFECTION STRATEGIES

Viral

Bacterial

Fungal

EARLY COMPLICATIONS

SURGICAL (biliary, vascular, etc.)

MEDICAL

ROLE OF HISTOLOGY AFTER PLT

ROLE OF RADIOLOGY AND INTERVENTIONAL RADIOLOGY AFTER PLT

LATE COMPLICATIONS

SURGICAL (graft re-modelling, secondary portal hypertension/shunts)

MEDICAL (recurrent disease post-PLT, de novo AIH, post-transplant lymphoproliferative disease, nephrotoxicity)

PSYCHOSOCIAL ASPECTS AFTER PLT

(social reintegration, medication adherence, family planning, education)

PROSPECTS FOR IMMUNE TOLERANCE (possibilities for safe withdrawal of immunosuppression)

TRANSITION TO ADULT SERVICES (smooth handover of care to a different system)

FUTURE REQUIREMENTS