The field of rheumatology has undergone numerous exciting advances in recent years, especially the development of biological drugs with novel targets, made possible by rapid advances in the basic science of musculoskeletal diseases together with improved imaging techniques. This thoroughly revised fourth edition of the Oxford Textbook of Rheumatology reflects the changing face of the specialty and the many recent advances in the science, treatment, and understanding of rheumatic diseases.
The focus of this comprehensive reference work is the presentation and management of rheumatic conditions at all ages. Where relevant, treatment approaches are evidence-based and cross-referenced to national and international guidelines. Each clinical chapter provides up-to-date treatment advice illustrated with clinical vignettes as appropriate, and the authors consistently emphasize the overlap of rheumatology with other disciplines. With full colour illustrations throughout and a complementary online version, the Oxford Textbook of Rheumatology, Fourth Edition is an essential reference for all trainees and specialists in the field.
Contents
Section 1 Clinical presentations of rheumatic disease in different age groups
1: The child patient, Lori Tucker
2: Young people and transitional care in rheumatology, Janet E. McDonagh
3: The adult patient, Paul Thompson
4: The elderly patient, Fraser Birrell
5: Principles of clinical examination in children, Helen Foster
6: Principles of clinical examination in adults, Lesley Kay
Section 2 Common clinical problems of rheumatic disease
7: Monoarticular disease, Marc Lillicrap
8: Oligoarticular disease, Andrew Keat
9: Polyarticular disease, Ade Adebajo
10: The systemically ill patient, Raashid Luqmani
11: Spinal pain, Karl Gaffney
12: Pain and Fatigue, Candy McCabe & Helen Cohen
13: The limping child, Yuki Kimura
14: The systemically unwell child, Athimalaipet Ramanan
15: Primary care presentation, Elspeth Wise
Section 3 Clinical presentations: Views from different perspectives
16: Obstetrics and pregnancy, Monika Oestensen
17: The skin, Christopher Griffiths
18: The nervous system, Andrew Graham & Clare Galton
19: The cardiovascular system, Gerry Coghlan
20: The respiratory system
21: The gastrointestinal system, Gerhard Rogler
22: The neuroendocrine system, Rainer Straub
23: Malignancy, Clive Kelly
24: The eye, Miles Stanford
25: The kidney, Mark Little
26: Psychology, Stanton Newman
Section 4 The impact of rheumatic disease
27: Epidemiology of rheumatic diseases, Deborah Symmons
28: Assessment of rheumatic disease, Piet van Riel
29: Outcomes, David L. Scott
30: Design of clinical trials in rheumatology, Vibeke Strand
31: Health economics, Sonja Merkesdal & Wilfried Mau
32: Co-morbidities of rheumatic disease, Tuulikki Sokka
33: Social aspects (work), Ross Wilkie
34: Biologics registries, David Isenberg & Angela Zink
35: Outcomes of paediatric rheumatic disease, Kirsten Minden
36: Assessment of paediatric rheumatic disease, Ciaran Duffy
Section 5 Genetics and environment
37: Basics of genetics, Anne Barton
38: Environment, Cyrus Cooper
39: Epigenetics, Steffen Gay and Michel Neidhart
40: Genetics of rheumatoid arthritis, Sebastien Viatte
41: Genetics of Spondyloarthropathies, Matthew Brown
42: Genetics of Connective tissue diseases, Tim Vyse
43: Genetics of juvenile rheumatic disease, Wendy Thomson & Anne Hinks
44: Genetics of osteoarthritis, Alexander Macgregor
45: Genetics of chronic musculoskeletal pain, John McBeth
Section 6 Tissue in health and disease
46: The normal functional anatomy of joints, Mike Benjamin
47: Measuring movement and gait, Lindsey Hooper
48: Innate vs. acquired immunity, Reinhard Voll
49: T Cellular side of acquired immunity (T cells), Pierre Miossec
50: Cellular side of acquired immunity (B cells), Thomas Dörner
51: Fibroblasts and mesenchymal cells, Chris Buckley
52: Synovial pathology, Costantino Pitzalis
53: Bone turnover, Georg Schett
54: Enthesitis, Martin Rudwaleit
55: Skeletal muscle physiology and damage, Robert Dinser
56: Joint biochemistry, Thomas Pap
57: Vascular biology, Justin Mason
58: Acute phase responses and adipocytokines, Elena Neumann
59: Pain neurophysiology, Rainer Straub & Hans-George Schaible
60: The pathogenesis of juvenile idiopathic arthritis, Lucy Wedderburn
Section 7 Practical investigation of rheumatic disease
61: Haematology, Patrick Kesteven
62: Biochemical investigation of rheumatic diseases, Patrick Twomey
63: Auto-immune serology, Neil McHugh
64: Complement, Matthew Pickering
65: Limb anatomy and medical imaging, Mike Benjamin
66: Radiographic imaging, Andrew Grainger
67: Ultrasound, Phil Platt
68: Magnetic resonance imaging, Phil O'Connor
69: Computed tomography, Geoff Hide
70: Nuclear medicine, Adil Al-Nahhas
71: Imaging in children, Karl Johnson
72: Assessment of synovial joint fluid, Tony Freemont
73: Cardiopulmonary investigation, Benjamin Schreiber
74: Electrophysiology, Julian Blake
Section 8 Management of rheumatic disease
75: Patient education, David Walker
76: Multidisciplinary treatment, Sarah Ryan
77: Cyclooxygenase inhibitors, Kay Brune
78: Analgesics, Philip Conaghan
79: Glucocorticoids, Frank Buttgereit
80: Immunosuppressants, Joanna Ledingham
81: Signalling pathway inhibitors, Roy Fleischmann
82: Anti-cytokine biologics, Andrew Östör
83: Cellular therapies, John Isaacs
84: Biologics in paediatric rheumatic diseases, Daniel Lovell
85: Stem cell therapies, Alan Tyndall
86: Tissue engineering, Andrew McCaskie
87: Injection therapy, Phil Platt
88: Diet and obesity, Dorothy Pattison
89: Alternative therapies, Edzard Ernst
90: Principles of upper limb surgery, Ian McNab
91: Principles of lower limb surgery, Damien Griffin
92: Principles of spine surgery, Jeremy Fairbank
93: Perioperative management of immunosuppression, Loreto Carmona
94: Vaccination in immunocompromised adults, Van Assen
95: Vaccination in immunocompromised children, Nico Wulffraat
96: Principles of management of juvenile idiopathic arthritis, Ravelli & Ruperto
97: Anti-rheumatic drugs in pregnancy and lactation, Tarnya Marshall
Section 9 Infection in rheumatic disease
98: Septic arthritis in adults, Max Field
99: Bone and joint infections in children, Julia Clark
100: Osteomyelitis, Jeremy Field
101: Lyme disease, Andreas Krause
102: Viral arthritis, Stanley J. Naides
103: Mycobacterial diseases, Rita Abdulkader
104: Brucellar arthritis, Eliseo Pascual
105: Parasitic involvement, Yusuf Patel
106: Fungal arthritis, Richard Watts
107: Opportunistic infection, Susan Hopkins
108: Rheumatic fever, Andrew C. Steer
Section 10 Rheumatoid arthritis
109: Pathogenesis of rheumatoid arthritis, Andy Cope
110: Rheumatoid arthritis - diagnosis, Daniel Aletaha
111: Rheumatoid arthritis - clinical features, Gerd Burmester
112: Rheumatoid arthritis - management, Chris Deighton
Section 11 Spondyloarthropathies
113: Axial Spondyloarthritis, Joachim Sieper
114: Psoriatic arthritis, Philip Helliwell
115: Reactive arthritis and enteropathic arthropathy, J.S. Hill Gaston
Section 12 Arthropathies primarily occuring in childhood
116: Juvenile idiopathic arthritis, Eileen Baildam
Section 13 Systemic lupus erythematosus
117: Systemic lupus erythematosus - clinical features and aetiopathogenesis, Caroline Gordon
118: Systemic lupus erythematosus - management, David Isenberg
119: Paediatric onset systemic lupus erythematosus, Michael Beresford
120: The antiphospholipid antibody syndrome, Munther A. Khamashta
Section 14 Scleroderma
121: Systemic sclerosis, Chris Denton
122: Paediatric scleroderma and related disorders, Francesco Zulian
123: Nephrogenic systemic fibrosis, Cate Orteu
Section 15 Myositis
124: Polymyositis and dermatomyositis in adults, Hector Chinoy
125: Paediatric polymyositis and dermatomyositis, Clarissa Pilkington
126: Non-inflammatory myopathies, Mark Roberts
Section 16 Sjögren's syndrome
127: Sjögren's syndrome: clinical features, Simon Bowman
128: Sjögren's syndrome: management, Wan-fai Ng
Section 17 Overlap/undifferentiated syndrome
129: Overlap/undifferentiated syndrome, Ariane Herrick
Section 18 Vasculitis
130: Classification and diagnosis, Richard A.Watts
131: Clinical features of primary ANCA-associated vasculitis, Julia Holle
132: Treatment of ANCA vasculitis, David Jayne
133: Large vessel vasculitis, Carlo Salvarani
134: Polymyalgia rheumatica, Charles Raine
135: Behcet's syndrome, Hasan Yaziçi
136: Paediatric vasculitis, Paul Brogan
137: Miscellaneous vasculitides, Richard A. Watts
Section 19 Osteoarthritis
138: Pathogenesis of osteoarthritis, Tonia Vincent
139: Clinical features of osteoarthritis, Mike Doherty
140: Osteoarthritis management, Phil Conaghan
Section 20 Crystal arthropathies
141: Gout, Nicola Dalbeth
142: Calcium pyrophosphate crystal deposition (CPPD), Ed Roddy
Section 21 Diseases of bone and cartilage
143: Osteoporosis, David Reid
144: Paget's disease of bone, Stuart Ralston
145: Paediatric metabolic bone disease, Nick Bishop
146: Disorders of bone mineralisation: Osteomalacia, Ashok Bhalla
147: Bone Tumours, Craig Gerrand
148: Avascular necrosis, Stefan Rehart
149: Renal osteodystrophy, Thomas Bardin
150: Skeletal dysplasias, Paul Wordsworth
Section 22 Regional rheumatic disease
151: Shoulder, Andrew Ostor
152: Elbow, Karen Walker-Bone
153: Forearm, hand and wrist, Karen Walker-Bone
154: Pelvis, groin and thigh, Cathy Speed
155: Knee, Roger Wolman
156: Foot and ankle, Tony Redmond
157: Cervical and lumbar spine, David Walsh
158: Childhood regional conditions, Kristin Houghton
159: Hypermobility syndromes, Alan Hakim
160: Fibromyalgia and chronic widespread pain syndromes: adult onset, Nick Shenker
161: Fibromyalgia and chronic widespread pain syndromes: adult onset, Jacqui Clinch
162: Sports and exercise injuries, Nicola Maffulli
Section 23 Miscellaneous conditions
163: Amyloidosis, Phil Hawkins
164: Auto-inflammatory diseases, Helen Lachmann
165: Panniculitides, Cord Sunderkotter
166: Neutrophilic dermatoses, Thomas Krieg
167: Sarcoidosis, Joachim Mueller-Quernheim
168: Macrophage activation syndrome, Alexei Grom
169: Multicentric reticulohistiocytosis, Hermann Einsele
170: Inherited metabolic diseases, Bernard Manger
171: The rheumatological manifestations of endocrine disorders, Gerry Rayman
172: Haemoglobinopathies, David Rees
173: Haemochromatosis, Graeme Carroll
