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The second edition of Cancer and the Heart was inspired by the rapid pace of advancement in the field and the continued need for integration of information about the complex interactions of multiple disease states in patients. Much new information is included in this edition, and the introduction of new agents approved for the care of patients with cancer has increased the interest in the discipline of cardiotoxicity. The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non-cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social and economic issues of the cancer patient with heart disease. CONTENTS 1. Cardiovascular Biology, Physiology and Malignancy 2. Doxorubicin cardiotoxicity: Clinical aspects, recognition, monitoring, treatment and prevention 3. Cardiotoxicity of Other Anthracyclines and their Analogues 4. Reduction of Doxorubicin Cardiotoxicity by the use of Liposomal Formulations of Doxorubicin 5. Chemical Cardioprotection against Anthracycline Cardiotoxicity 6. Trastuzumab-associated Cardiotoxicity 7. Effects of Radiation on the Heart 8. Cardiotoxicity of Other Chemotherapeutic Agents 9. Management of Congestive Heart Failure 10. Dysrhythmia in the Cancer Patient 11. Echocardiography in the Cancer Patient 12. Nuclear Imaging in the Cancer Patient 13. Cardiac Imaging with CT and MRI in oncology patients 14. Preoperative Assessment of the Cancer Patient for Non Cardiovascular Surgery 15. The Pericardium in the Cancer Patient 16. Pediatric Cardiac Neoplasia & Cancer Therapy Related Cardiovascular Disease 17. Cardiac Emergencies in the Cancer Patient 18. Heart-Lung Interactions in the Cancer Patient 19. Chronic Kidney Disease and its Relation to Cardiac 20. The Surgical Approach to Cardiac Tumors 21. Psycho-social and Non-pharmacologic Management of the Cancer Patient with Heart Failure Michael S. Ewer, MD Internist, Associate Professor of Medicine The University of Texas MD Anderson Cancer Center Houston, Texas - Edward T. H. Yeh, MD Professor, Chairman of Cardiology The University of Texas MD Anderson Cancer Center Houston, Texas
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