This second edition comes at a time of a paradigm shift in understanding of the molecular pathology and neuroscience of brain and spinal tumors of childhood and their mechanisms of growth within the developing brain. Excellent collaborative translational networks of researchers are starting to drive change in clinical practise through the need to test many ideas in trials and scientific initiatives. This text reflects the growing concern to understand the impact of the tumour and its treatment upon the full functioning of the child’s developing brain and to integrate the judgments of the risks of acquiring brain damage with the risk of death and the consequences for the quality of life for those who survive. Information on the principles of treatment has been thoroughly updated. A chapter also records the extraordinary work done by advocates. All medical and allied professionals involved in any aspect of the clinical care of these patients will find this book an invaluable resource.
Table of Contents
List of Contributors
1. Introduction
David A. Walker, Giorgio Perilongo, Roger E. Taylor, and Ian F. Pollack
2. Epidemiology of Childhood Brain Tumors
Richard J. McNally and Paul Graham Fisher
3. Clinical Presentation and Associated Syndromes of Brain Tumor
David Walker, JoFen Liu, and Dhurgsharna Shanmugavadivel
4. Pediatric Central Nervous System Tumors as Phenotypic Manifestation of Cancer Predisposition Syndromes
Giorgio Perilongo, Irene Toldo, and Stefano Sartori
5. Anatomical and Biological Imaging of Pediatric Brain Tumor
Rob A. Dineen, Shivaram Avula, Andrew C. Peet, Giovanni Morana, and Monika Warmuth- Metz
6. Neurosurgical Techniques and Strategies
Jonathan E. Martin, Ian F. Pollack, and Robert F. Keating
7. Radiotherapy for Pediatric Central Nervous System Tumors – Techniques and Strategies
Nicola Thorp
8. Physical and Cognitive Rehabilitation for Children with Brain and Spinal Tumors
Alexandra M. Gaynor, Helen Hartley, and Stephen A. Sands
9. Drug Delivery
Gudrun Fleischhack, Martin Garnett, and Kévin Beccaria
10. Low- grade Glioma Presenting in the Optic Pathways and Hypothalamus (NF1. and Sporadic)
Peter M.K. de Blank, Ian Simmons, Astrid Sehested, and Michael J. Fisher
11. Low- grade Glioma: Principles of Diagnosis and Drug Treatment
Pablo Hernáiz Driever, Olaf Witt, Astrid Gnekow, Daniela Kandels, and Mark Kieran
12. High- grade Glioma
Donald C. Macarthur, Christof M. Kramm, and Matthias A. Karajannis
13. Diff use Intrinsic Pontine Glioma
Katherine E. Warren, Carolyn R. Freeman, and Dannis G. van Vuurden
14. Embryonal Tumors
Simon Bailey and Jeff Michalski
15. Ependymoma in Childhood and Adolescence
Richard Grundy and Eric Bouffet
16. Germ Cell Tumors of the Central Nervous System
Matthew J. Murray, Ute Bartels, and James C. Nicholson
17. Atypical Teratoid / Rhabdoid Tumors – AT/ RT
Michael C. Frühwald, Jaclyn A. Biegel, and Susan N. Chi
18. Craniopharyngioma
Hermann L. Müller, Claire Alapetite, and Jeffrey Wisoff
19. Choroid Plexus Tumors and Meningiomas
Kenneth K. Wong, Elwira Szychot, Jennifer A. Cotter, and Mark Krieger
20. Pediatric Spinal Tumors
Rajiv R. Iyer, Nir Shimony, Mohammad Hassan A. Noureldine, Eric Bouffet, and George I. Jallo
21. Late Effects of Treatment for Childhood Brain and Spinal Tumors
Ralph Salloum, Katherine Baum, Melissa Gerstle, Helen Spoudeas, and Susan R. Rose
22. The Power of Patient Advocacy in Pediatric Neuro-oncology
Kathy Oliver, Susan Awrey, Mark Brougham, Gloria Garcia Castellvi, Anita Granero, Rakesh Jalali, Sacha Langton-Gilks, Yuko Moue, Kathy Riley, Bonita Suckling, Hisato Tagawa, and Raees Tonse
Index
