Brain Tumors

Meet the increasing need for effective brain tumor management with the highly anticipated revision of Brain Tumors by Drs. Andrew H. Kaye and Edward R. Laws. Over the past decade, enormous advances have been made in both the diagnosis and the surgical and radiotherapeutic management of brain tumors. This new edition guides you through the latest developments in the field, including hot topics like malignant gliomas, functional brain mapping, neurogenetics and the molecular biology of brain tumors, and biologic and gene therapy. You’ll also have easy access to the complete contents online, with links to PubMed and a downloadable image library, at www.expertconsult.com. New to this edition * Access the complete searchable contents online at www.expertconsult.com, with links to PubMed and a downloadable image library. * Stay up to date with the latest developments in the field, including management of malignant gliomas; functional brain mapping; neurogenetics and the molecular biology of brain tumors; biologic and gene therapies; and much more. * Apply the expert’s best practices with their key points . By Andrew H. Kaye, MB BS MD FRACS, Head of Department and James Stewart Professor of Surgery. Department of Surgery, The University of Melbourne, The Royal Melbourne Hospital, Melbourne, Victoria, Australia and Edward R. Laws, MD, PhD, W. Gayle Crutchfield Professor of Neurological Surgery, Professor of Clinical Internal Medicine and Pediatrics, University of Virginia Health Sciences Center, Charlottesville, VA Table of Contents: 1 Historical perspective 1 2 Stem cells and progenitor cell lineages in the central nervous system 6 3 Classification and pathogenesis of brain tumors 36 4 Epidemiology of brain tumors 59 5 Neurogenetics and the molecular biology of human brain tumors 83 6 Biologic therapy for malignant glioma 102 7 Gene therapy for human brain tumors 114 8 Immunology of brain tumors and implications for immunotherapy 125 9 Histopathology of brain tumors 138 10 Advanced imaging of brain tumors 188 11 Neuro-ophthalmology of brain tumors 214 12 Epilepsy associated with brain tumors 237 13 Anesthesia and intensive care management of patients with brain tumors 249 14 Surgical principles in the management of brain tumors 282 15 Radiosurgery and radiotherapy for brain tumors 296 16 Clinical trials and chemotherapy 306 17 Mouse models for brain tumor therapy 316 18 Management of brain tumors in the pediatric patient 329 19 Management of recurrent gliomas and meningiomas 347 20 Low-grade astrocytomas 372 21 Glioblastoma and malignant astrocytoma 384 22 Oligodendroglioma 408 23 Brainstem tumors 424 24 Intracranial ependymomas 435 25 Choroid plexus tumors 450 26 Uncommon glial tumors 462 27 Medulloblastoma and primitive neuroectodermal tumors 503 28 Acoustic neurinoma (vestibular schwannoma) 518 29 Other schwannomas of cranial nerves 570 30 Brain tumors associated with neurofibromatosis 588 31 Meningiomas 600 32 Meningeal hemangiopericytomas 630 33 Meningeal sarcomas 638 34 Pineal cell and germ cell tumors 646 35 Non-functional pituitary tumors 672 36 Diagnostic considerations and surgical results for hyperfunctioning pituitary adenomas 692 37 Chordomas and chondrosarcomas of the skull base 723 38 Glomus jugulare tumors 743 39 Carcinoma of the paranasal sinuses 750 40 Esthesioneuroblastoma: management and outcome 767 41 Primary central nervous system lymphoma 779 42 Craniopharyngiomas 807 43 Dermoid, epidermoid, and neurenteric cysts 831 44 Colloid cysts 849 45 Metastatic brain tumors 864