Neuroscientific Foundations of Anesthesiology

Although the perioperative care of patients by anesthesiologists draws on diverse clinical skills, the principles of anesthesiology and pain management are rooted in the neurosciences. The Neuroscientific Foundations of Anesthesiology thoroughly examines the anesthetic modulation of the central, peripheral, and autonomic nervous systems and will help redefine anesthesiology as a fundamentally neuroscientific field. The book is organized by sections, with each focusing on a different part of the nervous system. State-of-the-art chapters written by thought-leaders in anesthesiology and neuroscience provide a novel and invaluable resource. * Uniquely covers anesthesiology as a neuroscientific field * Extensive chapters are organized by systems for easy understanding * An invaluable resource for both clinicians and scientists in anesthesiology and neuroscience * Covers anesthetic neurotoxicity, a topic of current controversy and importance George A. Mashour , Director, Division of Neuroanesthesiology, University of Michigan Medical School, and Edited by Ralph Lydic , Bert La Du Professor of Anesthesiology, University of Michigan Medical School CONTENTS   I. Introduction II. Brain 1: Brain Anatomy of Relevance to the Anesthesiologist 2: Cellular and Molecular Effects of General Anesthetics in the Brain 3: The Shared Circuits of Sleep and Anesthesia 4: Thalamocortical System and Anesthetic-induced Unconsciousness 5: Anesthetic Modulation of Memory Processing in the Medial Temporal Lobe 6: Neuroimaging Changes Associated with Human Acute and Chronic Pain III. Spinal Cord 7: Spinal Cord Targets of Relevance to the Anesthesiologist 8: Anesthetic-Induced Immobility 9: Mechanisms of Spinal Analgesia IV. Peripheral Nervous System 10: Peripheral Nervous System: Anatomy and Function 11: The Neurobiology of Incisional Pain 12: Sequelae of Nerve injury: Neuropathic Pain and Complex Regional Pain Syndrome V. Autonomic Nervous System 13: The Autonomic Nervous System 14: Anesthetic Pharmacology of the Autonomic Nervous System VI. Neuromuscular Junction 15: Review of neuromuscular junction anatomy and function 16: Pharmacology of Neuromuscular Blockers 17: Anesthesia and Disorders of the Neuromuscular System VII. Neural Toxicity Induced by Anesthetics 18: Anesthesia-mediated neurotoxicity 19: Post-Operative Cognitive Disorders 20: Anesthesia and Neurodegenerative Disorders Index